Despite the increased use of beta-blockers in pregnancy, there is only limited information on their possible teratogenic effects. Beta-blockers could reduce uteroplacental blood flow and could therefore lead to congenital anomalies in the offspring.
Are beta blockers safe during pregnancy?
Beta-blocker exposure in pregnancy does not increase risk for fetal cardiac anomalies after adjusting for maternal comorbidities, according to a research letter published in JAMA Internal Medicine. “Beta-blockers are the most commonly used class of medication for treating cardiac conditions in pregnant women.
Why are beta blockers contraindicated?
Traditional contraindications to beta-blockers are peripheral vascular diseases, diabetes mellitus, chronic obstructive pulmonary disease (COPD) and asthma.
Which beta blocker is not safe in pregnancy?
Conclusions The authors found that exposure to β-blockers during pregnancy was associated with being born SGA, preterm birth and perinatal mortality. Our findings show that labetalol is not safer than other β-blockers during pregnancy.
Is propranolol contraindicated in pregnancy?
Propranolol Pregnancy Warnings
This drug is only recommended for use during pregnancy when there are no alternatives and the benefit outweighs the risk. Beta blockers may cause decreased placental perfusion, fetal and neonatal bradycardia, and hypoglycemia.
Can beta blockers cause birth defects?
Beta-blockers used to treat hypertension during the first trimester of pregnancy don’t appear to increase the risk that babies will be born with birth defects or cardiac malformations, according to an analysis of observational data on more than 18,000 women across five Nordic countries and the United States.
Do beta blockers cross placenta?
β-Blockers are the most commonly used class of medication for treating cardiac conditions in pregnant women. Despite the common use of this class of medication, data that support its safety are limited. β-Blockers cross the placenta and potentially can cause physiological changes in the fetus.
Who Cannot take beta blockers?
You cannot take a beta-blocker if you have certain conditions, including:
- Uncontrolled heart failure.
- Very slow heart rate (bradycardia).
- Low blood pressure (hypotension).
- Certain problems with the rhythm of your heart – eg, sick sinus syndrome.
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Can beta blockers damage your heart?
When taken in very high doses, beta blockers can worsen heart failure, slow the heart rate too much, and produce wheezing and a worsening of lung disease. High doses may also cause lightheadedness from a drop in blood pressure, which puts people at risk for falls and injury.
Which beta blocker has the least amount of side effects?
A cardioselective beta-blocker such as bisoprolol or metoprolol succinate will provide the maximum effect with the minimum amount of adverse effects.
Are Beta Blockers Safe?
These drugs also increase the chances of living longer and better with heart failure. The reviewers found that different beta blockers work better for different conditions. Safety. Beta blockers are generally safe to take.
Is metoprolol OK for pregnancy?
Metoprolol Pregnancy and Breastfeeding Warnings
US: This drug should be used during pregnancy only if clearly needed.
Will labetalol affect my baby?
Labetalol is not thought to harm an unborn baby. But there’s a small chance that when your baby’s born the medicine can affect their blood sugar levels. For this reason your baby may be monitored for the first 24 hours to make sure everything is OK.
Can propranolol cause a miscarriage?
Can taking propranolol in pregnancy cause miscarriage? A single study provided no evidence that use of propranolol in early pregnancy was linked to an increased risk of miscarriage. No further studies have assessed miscarriage rates in women taking propranolol and more research into this subject is therefore required.
What medications should not be taken with propranolol?
People taking propranolol should also avoid nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen. These drugs may reduce the effects of propranolol. If a person needs to take NSAIDs, they should work directly with a doctor.
What antihypertensive is safe in pregnancy?
Acceptable agents include methyldopa, labetalol, and nifedipine in standard doses. Atenolol use should probably be avoided in pregnancy, because it has been associated with slightly lower birth weights.